Cloning, expression, isolation and characterization of the pre-S domains of hepatitis B surface antigen, devoid of the S protein

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Cloning, expression, isolation and characterization of the pre-S domains of hepatitis B surface antigen, devoid of the S protein.

The 'pre-S' parts of the envelope protein of hepatitis B virus (HBV) have been proposed to be involved in the infection of hepatocytes by HBV. In order to facilitate the study of these processes, we have developed an expression system to allow the production and purification of large quantities of the pre-S protein. To obtain a protein containing all of the pre-S sequence and only this sequence...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1991

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj2760411